FGETS: Food and Gill Exchange of Toxic SubstancesFGETS is a simulation program that predicts temporal dynamics of a fish's whole body concentration (µg chemical /(grams live weight fish)) of non-ionic, non-metabolized, organic chemicals that are bioaccumulated from water and food.
The model is based on a set of diffusion and forced convection partial differential equations, coupled to a process-based fish growth formulation.
Chemical exchange rates are estimated using fundamental principles of passive diffusion and thermodynamics rather than phenomenological toxicokinetic data.
FETS can be used to analyze the bioaccumulation of organic chemicals
under laboratory or field conditions, and its predictions have
been shown to agree well with both types of data.
The model considers both biological attributes of the fish and
physico-chemical properties of the chemical that determine diffusive
exchange across gill membranes and intestinal mucosa. Important
biological characteristics used by the model include the fish's
gill morphometry, body weight, and fractional aqueous, lipid,
and structural organic composition. Relevant physico-chemical
properties are the chemical's aqueous diffusivity, molar volume,
and n-octanol/water partition coefficient (Kow)).
FGETS also calculates the time to reach a lethal activity in the fish assuming that the chemical has a narcotic mode of action.
SOFTWARE AVAILABILITYThe program is available at:
Center for Exposure Assessment Modeling (CEAM)
U.S. Environmental Protection Agency
Office of Research and Development
Environmental Research Laboratory
960 College Station Road
Athens, Georgia 30605-2720
The software ca be downloaded at the EPA-CEAM FGETS page
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